[vc_row css=”.vc_custom_1489054094342{padding-top: 0px !important;padding-bottom: 250px !important;background-image: url(http:\/\/www.adrianaduelo.com\/wp-content\/uploads\/2017\/03\/capcalera-sintomas-tratamientos2.jpg?id=10418) !important;}”][vc_column][vc_column_text]<\/p>\n
[\/vc_column_text][\/vc_column][\/vc_row][vc_row css=”.vc_custom_1487856671367{padding-top: 40px !important;}”][vc_column][vc_column_text]<\/p>\n
[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]Migraine is a complex syndrome and headache<\/strong>, normally unilateral and pulsating, is the most important clinical sign.<\/strong>. Most of the crisis are accompanied by sensitivity to noise<\/strong>, light<\/strong>, odours<\/strong> or movement<\/strong>, as well as by loss of appetite<\/strong>, sickness<\/strong>, nausea<\/strong>, vomiting<\/strong> and cold or hot feeling<\/strong>.<\/p>\n A migraine episode is variable regarding intensity, frequency or duration, and could last 72 hours in adults. Headache is mainly located in the temples area<\/strong> and appears at certain time intervals when the pain occurs.[\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column width=”1\/2″][vc_column_text css_animation=”left-to-right” css=”.vc_custom_1489062880121{padding-top: 15px !important;padding-right: 15px !important;padding-bottom: 15px !important;padding-left: 15px !important;background-color: #fff4e2 !important;border-radius: 5px !important;}”]Migraine affects between 12% and 17% of western population and approximately three out of four migrainous individuals are women. Therefore, women represent 75% of the sufferers versus 25% of men.<\/span>[\/vc_column_text][vc_column_text]Migraine has been treated during decades with the same type of drugs without achieving neither a cure nor a significant improvement without presenting adverse effects<\/strong>. Some of the most common are antidepressant drugs, anticonvulsants, analgesics, anti-inflammatories or triptans. Beyond, even some doctors are using a muscle-paralysing toxin. It sounds chilling, but it is a trend.<\/p>\n Fortunately, in the last years, the treatment of this syndrome is facing a drastic change<\/strong>. There is a growing number of research groups studying the organic origin of migraine, and point to two molecules: histamine and Diamine Oxidase (DAO). In fact, the role of histamine in migraine is key<\/strong>, and it was already described by Krabbe AA in a study carried out in 1980. During this study, 48 patients were given endovenous histamine and more than half of this sample ended up with migraine or headaches as a result of the muscle spasms they suffered. Most of the migraine crisis appear when an accumulation of histamine occurs due to lack of activity of the intestinal enzyme DAO<\/strong>. Histamine taken through food passes to the bloodstream and reaches different body tissues, one of them, cerebral arteries. At this point, histamine causes vasodilatation and, as a result, the symptoms appear. \u00a0\u00a0[\/vc_column_text][\/vc_column][vc_column width=”1\/2″][vc_single_image image=”10505″ img_size=”full” alignment=”center”][\/vc_column][\/vc_row]<\/p>\n","protected":false},"excerpt":{"rendered":" [vc_row css=”.vc_custom_1489054094342{padding-top: 0px !important;padding-bottom: 250px !important;background-image: url(http:\/\/www.adrianaduelo.com\/wp-content\/uploads\/2017\/03\/capcalera-sintomas-tratamientos2.jpg?id=10418) !important;}”][vc_column][vc_column_text] Symptoms and treatments [\/vc_column_text][\/vc_column][\/vc_row][vc_row css=”.vc_custom_1487856671367{padding-top: 40px !important;}”][vc_column][vc_column_text] Migraine [\/vc_column_text][\/vc_column][\/vc_row][vc_row][vc_column][vc_column_text]Migraine is a complex syndrome and headache, normally unilateral and pulsating, is the most […]<\/p>\n","protected":false},"author":13,"featured_media":0,"parent":10469,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/www.adrianaduelo.com\/en\/wp-json\/wp\/v2\/pages\/10472"}],"collection":[{"href":"https:\/\/www.adrianaduelo.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.adrianaduelo.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.adrianaduelo.com\/en\/wp-json\/wp\/v2\/users\/13"}],"replies":[{"embeddable":true,"href":"https:\/\/www.adrianaduelo.com\/en\/wp-json\/wp\/v2\/comments?post=10472"}],"version-history":[{"count":3,"href":"https:\/\/www.adrianaduelo.com\/en\/wp-json\/wp\/v2\/pages\/10472\/revisions"}],"predecessor-version":[{"id":10508,"href":"https:\/\/www.adrianaduelo.com\/en\/wp-json\/wp\/v2\/pages\/10472\/revisions\/10508"}],"up":[{"embeddable":true,"href":"https:\/\/www.adrianaduelo.com\/en\/wp-json\/wp\/v2\/pages\/10469"}],"wp:attachment":[{"href":"https:\/\/www.adrianaduelo.com\/en\/wp-json\/wp\/v2\/media?parent=10472"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}The role of histamine in migraine is key<\/h3>\n
\nHereinafter, more scientific studies were conducted proving the above said relationship and found out the mechanism by which histamine accumulates in certain individuals.<\/p>\n