{"id":12465,"date":"2019-10-04T17:55:16","date_gmt":"2019-10-04T15:55:16","guid":{"rendered":"http:\/\/www.adrianaduelo.com\/?p=12465"},"modified":"2023-10-16T21:15:36","modified_gmt":"2023-10-16T19:15:36","slug":"is-dao-deficiency-hereditary","status":"publish","type":"post","link":"https:\/\/www.adrianaduelo.com\/en\/is-dao-deficiency-hereditary\/","title":{"rendered":"Is DAO Deficiency hereditary?"},"content":{"rendered":"
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Nowadays, we know that Diamine Oxidase deficiency (DAO deficiency) may be primary or secondary, which is the same as saying genetic or acquired. Therefore, DAO deficiency can be hereditary and in fact it is its main cause<\/strong>.<\/p>\n<\/blockquote>\n

It is important to remember that what we inherit is the enzymatic deficiency but not the symptomatology<\/span><\/strong>. In the same family we can find people with DAO deficiency, but with different associated symptoms<\/a>. For example: a mother with migraine and non-allergic rhinitis, a son with hives and digestive disorders and an uncle with chronic fatigue and digestive disorders.<\/p>\n

AOC1<\/strong> is the gene that codes for the synthesis of the DAO enzyme. When there is a genetic alteration in AOC1, the DAO enzyme produced has an abnormal structure and, consequently, less effective in its main function: the degradation of histamine from the diet<\/a>.<\/p>\n

What test should I request for?<\/strong><\/span><\/h2>\n

To know if the DAO deficiency has a genetic origin, a molecular genetic study of Diamino Oxidase deficit must be performed<\/strong>. In this study 4 variants<\/a> of the AOC1 gene are studied, which, in scientific literature, have been associated with reduced levels of DAO activity with a lower capacity for histamine degradation:<\/p>\n