{"id":16331,"date":"2024-07-01T14:16:42","date_gmt":"2024-07-01T12:16:42","guid":{"rendered":"https:\/\/www.adrianaduelo.com\/?p=16331"},"modified":"2024-10-24T20:00:07","modified_gmt":"2024-10-24T18:00:07","slug":"the-possible-relationship-between-dao-deficiency-and-celiac-disease","status":"publish","type":"post","link":"https:\/\/www.adrianaduelo.com\/en\/the-possible-relationship-between-dao-deficiency-and-celiac-disease\/","title":{"rendered":"The possible relationship between DAO deficiency and celiac disease"},"content":{"rendered":"

This article was written by Adriana Duelo, clinical nutritionist specialized<\/span><\/span>\u00a0in digestive pathologies and DAO deficiency, and published in the Mazorca magazine\u00a0<\/span>n\u00ba74 (magazine of The Spanish Federation of Coeliac Associations<\/a>).<\/p><\/blockquote>\n

If you are celiac<\/u> or you have a non-celiac gluten sensibility<\/u> (NCGS) and you have not yet started a gluten-free diet<\/span><\/strong><\/a> or you have only recently been on it, your intestinal villi may still be damaged. This means that you have a reduced part of the intestinal surface to absorb nutrients and synthesize digestive enzymes due to the few epithelial cells there are. Hence, a common characteristic among patients is the deficiency of certain minerals such as calcium<\/span><\/strong> or iron<\/strong><\/span>, vitamins<\/span><\/strong> such as D<\/span><\/strong> or\u00a0group\u00a0<\/span>B<\/strong><\/span>\u00a0and\/or digestive enzymes, such as <\/span>lactase<\/strong><\/span> or <\/span>diamine oxidase (DAO)<\/strong><\/span>.<\/span><\/p>\n

In 1986, Dr. Forget, a pediatrician at Bavi\u00e8re Hospital (Belgium), linked the DAO enzyme deficiency with celiac disease. His research focused on finding a less aggressive alternative to intestinal biopsy to diagnose celiac disease. Forget found that patients with celiac disease had the DAO activity enzyme reduced<\/u>, both in the intestinal mucosa and at the serum level. This result made him think that it could be a reflection of the low quality of the enterocytes (villus cells), a characteristic feature of a celiac intestine. This result gave rise to other researchers such as W.J. Schnedl, D. Enko and K. Griauzdait\u0117, among others, will seek more answers to the possibility that the DAO enzyme could be used as a biomarker to evaluate the intestinal status of people with celiac disease or NCGS<\/u>.<\/p>\n

But, how could this DAO deficiency affect us? Let’s first see what the DAO is and what its functions are:<\/strong><\/h3>\n

DiAmino Oxidase<\/span><\/strong> or DAO<\/strong><\/span> is a digestive enzyme located in the small intestine, synthesized by enterocytes and is responsible for metabolizing a molecule that we ingest through the diet, histamine<\/span><\/strong>. The primary function of DAO is to prevent histamine from entering the bloodstream. If histamine manages to enter, this inflammatory molecule can build up and lead to various symptoms.<\/span><\/p>\n

To suspect a possible DAO deficiency, it must be present two symptoms from different systems at least:<\/p>\n